5/25/2023 0 Comments 2002 turner xce reviews![]() ![]() Mary Lyon predicted that her XCI hypothesis, now deemed a law, would be applicable to humans ( Lyon 1962). Similar variegation in coat colour is seen in female mice with the Cattanach X autosome insertion ( figure 1a). She interpreted the variegated coat colour as due to clonal growth of cells with random silencing of one X chromosome ( Lyon 1961). tabby), and based on known facts at the time that X0 mice are viable ( Welshons and Russell 1959) and that female cells contain a heteropyknotic X chromosome ( Ohno and Hauschka 1960). ![]() Mary Lyon formulated her X-chromosome inactivation (XCI) hypothesis in 1961 based on her observations in female mice heterozygous for a mutation in an X-linked gene that controls coat colour (for e.g.
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